PRF1 Antibody - N-terminal region
Catalog Number:
ASB-ARP42208_P050
- Images (3)
| Article Name: | PRF1 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP42208_P050 |
| Supplier Catalog Number: | ARP42208_P050 |
| Alternative Catalog Number: | ASB-ARP42208_P050-25UL,ASB-ARP42208_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Canine, Equine, Human, Porcine, Rabbit |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human PRF1 |
| Alternative Names: | P1, PFP, HPLH2 |
| PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. |
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WB Suggested Anti-PRF1 Antibody Titration: 0.2-1 ug/ml Positive Control: MCF7 cell lysate |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. |
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PRF1 antibody - N-terminal region (ARP42208_P050) in Human MCF-7 using Western Blot |
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