HCAR2 Antibody - C-terminal region
Catalog Number:
ASB-ARP63888_P050
- Images (3)
| Article Name: | HCAR2 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP63888_P050 |
| Supplier Catalog Number: | ARP63888_P050 |
| Alternative Catalog Number: | ASB-ARP63888_P050-25UL,ASB-ARP63888_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Alternative Names: | HCA2, HM74a, HM74b, PUMAG, NIACR1, Puma-g, GPR109A |
| HCAR2 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. |
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WB Suggested Anti-HCAR2 Antibody Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell |
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Host: Rabbit Target Name: HCAR2 Sample Tissue: Human Stomach Tumor Antibody Dilution: 1.0ug/ml |
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HCAR2 antibody - C-terminal region (ARP63888_P050) in Human Stomach Tumor using Western Blot |
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