DIO3 Antibody - C-terminal region
Catalog Number:
ASB-OAAB06126
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| Article Name: | DIO3 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-OAAB06126 |
| Supplier Catalog Number: | OAAB06126 |
| Alternative Catalog Number: | ASB-OAAB06126-400UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | This DIO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3. |
| Alternative Names: | D3, 5DIII, TXDI3, DIOIII |
| DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. |
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