KLH conjugated synthetic phosphopeptide derived from human ATG1 around the phosphorylation site of Ser556
Conjugation:
Unconjugated
Alternative Names:
ATG1,ATG1 autophagy related 1 homolog,ATG1A,autophagy-related protein 1 homolog,hATG1,serine/threonine-protein kinase ULK1,UNC51,Unc51.1,Unc-51-like kinase 1.
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
