Recombinant Human RING finger and CHY zinc finger domain-containing protein 1 protein (1-261AA)
Conjugation:
Unconjugated
Alternative Names:
Androgen receptor N-terminal-interacting protein,androgen-receptor N-terminal-interacting protein,ARNIP,CHIMP,CH-rich interacting match with PLAG1,CH-rich-interacting match with PLAG1,E3 ubiquitin-protein ligase Pirh2,p53-induced protein with a RING-H2 domain,p53-induced RING-H2 protein,PIRH2,PRO1996,ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase,RING finger and CHY zinc finger domain-containing protein 1,RING finger protein 199,RING-type E3 ubiquitin transferase RCHY1,RNF199,ZCHY,zinc finger protein 363,zinc finger, CHY-type,ZNF363.
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.