CRBN Antibody
Catalog Number:
ASB-OACA09275
- Images (3)
| Article Name: | CRBN Antibody |
| Biozol Catalog Number: | ASB-OACA09275 |
| Supplier Catalog Number: | OACA09275 |
| Alternative Catalog Number: | ASB-OACA09275-100UL,ASB-OACA09275-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Protein cereblon protein (1-280AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | MRT2,MRT2A,protein cereblon,protein x 0001. |
| Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. |
| Clonality: | Polyclonal |
| Concentration: | Varies by lot. See vial for concentration. |
| NCBI: | 51185 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human heart tissue at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human thyroid tissue at dilution of 1:100 |
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Western blot All lanes: CRBN antibody at 4.65 ug/ml Lane 1: Mouse liver tissue |
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