YME1L1 Antibody
Catalog Number:
ASB-OACA09322
- Images (3)
| Article Name: | YME1L1 Antibody |
| Biozol Catalog Number: | ASB-OACA09322 |
| Supplier Catalog Number: | OACA09322 |
| Alternative Catalog Number: | ASB-OACA09322-100UL,ASB-OACA09322-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human ATP-dependent zinc metalloprotease YME1L1 protein (1-240AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | ATP-dependent metalloprotease FtsH1,ATP-dependent metalloprotease FtsH1 homolog,ATP-dependent zinc metalloprotease YME1L1,FTSH,meg-4,MEG4,OPA11,PAMP,presenilin-associated metalloprotease,YME1L,YME1-like protein 1. |
| ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). |
| Clonality: | Polyclonal |
| NCBI: | 10730 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution of 1:100 |
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Western blot All lanes: YME1L1 antibody at 3.8 ug/ml Lane 1: A549 whole cell ly |
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