Recombinant Human Oxysterols receptor LXR-beta protein (1-461AA)
Conjugation:
Unconjugated
Alternative Names:
liver X nuclear receptor beta,Liver X receptor beta,LX receptor beta,LXR-b,LXRB,NER,NER-I,nuclear orphan receptor LXR-beta,nuclear receptor NER,Nuclear receptor subfamily 1 group H member 2,oxysterols receptor LXR-beta,RIP15,steroid hormone-nuclear receptor NER,ubiquitously-expressed nuclear receptor,UNR.
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5-AGGTCA-3 and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8, DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
