DCDAPH (1,1-dicyano-6-(4-N,N-dimethylaminophenyl)-1,3,5-hexatriene) is a far-red fluorescent probe that has proved to have affinity to Abeta plaques. It has been used for fluorescent staining of brain sections, as well as in vivo detection of Abeta1-42 aggregates by small animal near-IR imaging. DCDAPH has high affinity (Ki= 37 nM, Kd=27 nM) to Abeta1-42 aggregates. Dark purple solid &lamba,Ex/&lamba,Em = 597/665 nm (PBS) Store at -20C and protect from light, especially in solution C16H15N3 MW: 249.31
Source:
Synthetic
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