Trametinib (DMSO solvate), CAS [[1187431-43-1]]
Catalog Number:
BYT-ORB1301426
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| Article Name: | Trametinib (DMSO solvate), CAS [[1187431-43-1]] |
| Biozol Catalog Number: | BYT-ORB1301426 |
| Supplier Catalog Number: | orb1301426 |
| Alternative Catalog Number: | BYT-ORB1301426-10, BYT-ORB1301426-50, BYT-ORB1301426-25, BYT-ORB1301426-100, BYT-ORB1301426-200 |
| Manufacturer: | Biorbyt |
| Category: | Biochemikalien |
| Alternative Names: | type, Trametinib, Trametinib (DMSO solvate), Trametinib dimethyl sulfoxide, Trametinib DMSO solvate, JTP74057, JTP-74057, JTP-74057 (DMSO solvate), JTP 74057, inhibit, Mitogen-activated protein kinase kinase, orally, Inhibitor, MEK1/2, MEK, MAPKK, MAP2K, GSK 1120212, GSK1120212, GSK-1120212, GSK-1120212 (DMSO solvate), AIA, Adjuvant-induced, arthritis, Apoptosis, CIA, collageninduced, DMSO solvate |
| Trametinib (DMSO solvate), also known as GSK1120212, is a highly potent and selective allosteric inhibitor of MEK1 and MEK2 kinases with an IC50 of 2 nM. It is widely used in both in vitro and in vivo cancer research, particularly for studying the MAPK/ERK pathway in melanoma, NSCLC, and other malignancies. |
| Molecular Weight: | 693.53 |
| Purity: | >99.99% (May vary between batches) |
| CAS Number: | [1187431-43-1] |
| Formula: | C28H29FIN5O5S |
| Target: | MEK,Apoptosis |
| Application Notes: | Solubility: DMSO:1.3 mg/mL (1.87 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.44 mM) |
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Chemical structure of Trametinib (DMSO solvate) |
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