U 9889, U9889, U-9889, RNASynthesis, RNA Synthesis, STZ, Streptozocin, Streptozotocin, Inhibitor, inhibit, NSC 85998, NSC85998, NSC-85998, DNA/RNA Synthesis, DNAAlkylator, DNAAlkylation, DNA Synthesis, DNASynthesis, DNA Alkylator, DNA alkylator, DNA Alkylation, DNA Alkylator/Crosslinker, Crosslinker, Autophagy, Bacterial, Antibiotic
Streptozotocin is a GLUT2-transported antibiotic that selectively induces pancreatic beta-cell apoptosis via DNA alkylation. It is extensively used to generate experimental models of diabetes in vivo and to study beta-cell toxicity in vitro. Due to its instability, fresh preparation in solution is required.
