inhibit, Parasite, Inhibitor, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite, Allopurinol riboside, DrugMetabolite, Drug Metabolite, Purine nucleoside phosphorylase
Allopurinol riboside, a metabolite of allopurinol, exhibits antiparasitic activity. It acts as a competitive inhibitor of purine nucleoside phosphorylase, with a Ki of 277 µM against inosine. This small molecule is used in biochemical research to study purine salvage pathways in parasites, relevant for both in vitro and in vivo experimental models.
