AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of 13 nM.
Molecular Weight:
1031.68
Purity:
>97%
CAS Number:
[2776190-62-4]
Formula:
C51H63ClN8O9S2
Chemical Structure: 2776190-62-4
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