CDH17/Cadherin-17 Antibody, Unconjugated, Monoclonal
Catalog Number:
BYT-ORB1805486
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| Article Name: | CDH17/Cadherin-17 Antibody, Unconjugated, Monoclonal |
| Biozol Catalog Number: | BYT-ORB1805486 |
| Supplier Catalog Number: | orb1805486 |
| Alternative Catalog Number: | BYT-ORB1805486-1,BYT-ORB1805486-100 |
| Manufacturer: | Biorbyt |
| Category: | Antikörper |
| Application: | ELISA, FA, FACS, In vivo |
| Species Reactivity: | Human |
| Conjugation: | Unconjugated |
| Anti-CDH17 / Cadherin-17 Reference Antibody is expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. It has a predicted MW of 143.68kDa. |
| Clonality: | Monoclonal |
| Concentration: | Batch dependent |
| Molecular Weight: | 143.68 kDa |
| UniProt: | Q12864 |
| Buffer: | 100 mM Proline/Acetic acid 20mM Arginine pH 5.0 |
| Purity: | >95% |
| Target: | CDH17 / Cadherin-17 |
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Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%. |
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The purity of Anti-CDH17 / Cadherin-17 Reference Antibody (10C12)is more than 98.15% ,determined by SEC-HPLC. |
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Immobilized human CDH17, His Tag at 2 µg/mL can bind Anti-CDH17 / Cadherin-17 Reference Antibody (10C12),EC50=0.00468µg/mL. |
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Human CDH17 HEK293 cells were stained with Anti-CDH17 / Cadherin-17 Reference Antibody (10C12) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC240=0.06889 µg/mL. |
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The endocytosis ratio 10C12 by Human CDH17 HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% at antibody concentration of 2 nM. |
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10C12 inhibited the tumor growth of COLO205 on nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 70.0% at 5 mpk at D26. |
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