CLDN6/CLD6 Antibody, Unconjugated, Monoclonal
Catalog Number:
BYT-ORB1806238
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| Article Name: | CLDN6/CLD6 Antibody, Unconjugated, Monoclonal |
| Biozol Catalog Number: | BYT-ORB1806238 |
| Supplier Catalog Number: | orb1806238 |
| Alternative Catalog Number: | BYT-ORB1806238-1,BYT-ORB1806238-100 |
| Manufacturer: | Biorbyt |
| Category: | Antikörper |
| Application: | ELISA, FA, FACS, In vivo |
| Species Reactivity: | Human |
| Conjugation: | Unconjugated |
| Anti-CLDN6 Reference Antibody is expressed from CHO. It has a predicted MW of 145.5 kDa. |
| Clonality: | Monoclonal |
| Concentration: | Batch dependent |
| Molecular Weight: | 144.42 kDa |
| UniProt: | P56747 |
| Buffer: | 100 mM Proline/Acetic acid 20mM Arginine pH 5.0 |
| Purity: | >95% |
| Target: | CLDN6 / CLD6 |
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Anti-CLDN6 Reference Antibody (IMAB027) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%. |
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The purity of Anti-CLDN6 Reference Antibody (IMAB027)is more than 98.41% ,determined by SEC-HPLC. |
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Immobilized human CLDN6 VLP at 8 µg/mL can bind Anti-CLDN6 Reference Antibody (IMAB027),EC50=0.001599µg/mL. |
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Human CLDN6 CHO cells were stained with Anti-CLDN6 Reference Antibody (IMAB027) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC199=4.342 nM. |
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Anti-CLDN6 Reference Antibody (IMAB027)-induced ADCC activity was evaluated using Human CD16a (158V) (Luc) Jurkat Reporter Cell. The max induction fold was approximately 14.16 |
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Anti-CLDN6 Reference Antibody (IMAB027),by huCLDN6-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM. |
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IMAB027 inhibited the tumor growth of OV90 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 50.7% at 5 mpk at D34. |
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