>85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie Blue stain.
Application Notes:
The E3 ligase activity is confined to the C-terminal domain of Mdm2 and is responsible for the ubiquitinylation and subsequent proteasomal degradation of p53, and can be SUMOylated which decreases autoubiquitinylation activity but increases activity toward p53.
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