PRKAB2, 5-AMP-activated protein kinase subunit beta-2, AMPK subunit beta-2
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
Western blot analysis of 1) 293T, 2) HepG2, 3) Mouse Heart Tissue, 4) Rat Heart Tissue using AMPKbeta2 Polyclonal Antibody. Secondary antibody(catalog:RS0002) was diluted at 1:20000
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