This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Western blot analysis of lysates from mouse heart and rat heart cells, using Glucokinase Regulator Antibody. The lane on the right is blocked with the synthesized peptide.
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