Nogo B Receptor Rabbit Monoclonal antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE02349
Supplier Catalog Number:
AMRe02349
Alternative Catalog Number:
EKL-AMRE02349-50UL, EKL-AMRE02349-100UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
NgBR, MRD55, CDG1AA, C6orf68, TANGO14, MGC:7199
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300).
