Cyclin D1 (10Z18) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE09589
Product Overview
Article Name:
Cyclin D1 (10Z18) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE09589
Supplier Catalog Number:
AMRe09589
Alternative Catalog Number:
EKL-AMRE09589-50UL, EKL-AMRE09589-100UL, EKL-AMRE09589-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
ICC, IHC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
CCND1,BCL1, D11S287E, PRAD1, U21B31, Cyclin D1,
Product Description
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162, PubMed: 33854235). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed: 1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162). Hypophosphorylates RB1 in early G(1) phase (PubMed: 1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed: 1833066, PubMed: 1827756, PubMed: 8302605, PubMed: 19412162). Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed: 15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed: 9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed: 16569215, PubMed: 18417529).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
34kDa
NCBI:
595
UniProt:
P24385
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
CCND1
Application Notes
Application Dilute:
WB 1:1000-1:2000,IHC 1:100-1:500,ICC/IF 1:100-1:200,IP 1:20-1:50
