SESN1, PA26, SEST1, Sestrin-1, p53-regulated protein PA26
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],disease:Defects in SESN1 may be involved in heterotaxia. Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems.,function:Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.,induction:Isoforms T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. Isoform T1 is not induced by p53.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,
