CD4 is an approximately 55/xa0kDa type/xa0I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T/xa0lymphocytes. It is a standard phenotype marker for the identification of T/xa0cell populations. Mature human CD4 consists of a 371/xa0amino acid extracellular region containing four immunoglobulin-like domains, a 22/xa0aa transmembrane segment, and a 40/xa0aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T/xa0cells during their development in the thymus. CD4 binds directly to MHC class/xa0II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1.
Greater than 95% as determined by reducing SDS-PAGE
Application Notes:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100µg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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