GST fusion protein containing cdc10-NCR region of mouse Notch1
Notch 1 is a 270-300 kDa transmembrane protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands such as DLL1, Jagged 1 (CD339), and Jagged 2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates into the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in bone marrow progenitor cells, brain, lung and thymus.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[mN1A]
Isotype:
Mouse IgG1 kappa
Buffer:
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
