Buloxibutid (hydrochloride), CAS [[1947313-60-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-100113A
Supplier Catalog Number:
HY-100113A
Alternative Catalog Number:
MCE-HY-100113A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
AT2 receptor agonist C21 (hydrochloride)
Buloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-beta/Smad pathway and inflammatory NF-kappaB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions[1][2][3][4].
