Netoglitazone (MCC-555) is an orally active PPARgamma ligand with an EC50 of 8 µM. Netoglitazone mediates cell type-specific functional regulation, and modulates the transcriptional activity of PPARgamma as a full agonist, partial agonist or antagonist. Netoglitazone induces adipogenesis, inhibits osteoblastogenesis, alters the weight of extramedullary fat depots and enhances insulin sensitivity. Netoglitazone reduces blood glucose levels. Netoglitazone can be used in research related to type 2 diabetes and non-insulin-dependent diabetes mellitus[1][2][3][4].
Molecular Weight:
381.42
Purity:
99.92
CAS Number:
[161600-01-7]
Formula:
C21H16FNO3S
Target:
PPAR
Application Notes:
MCE Product type: Reference compound1
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