1-EBIO (1-Ethyl-2-benzimidazolinone) is an activator of Ca2+ sensitive K+ channels wirh an EC50 of 136 µM for KCa3.1. 1-EBIO induces Cl- secretion, K+ conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death[1][2][3][4][5][6].
Molecular Weight:
162.19
Purity:
99.96
CAS Number:
[10045-45-1]
Formula:
C9H10N2O
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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