ZJ43 is a NAAG peptidase inhibitor and glutamate carboxypeptidase II/III (GCP II/III) inhibitor with human GCP II IC50 of 2.4 nM and Ki of 0.8 nM. ZJ43 blocks N-acetylaspartylglutamate hydrolysis, elevates extracellular N-acetylaspartylglutamate levels, and activates group II metabotropic glutamate receptors (mGluR). ZJ43 can be used for the research of schizophrenia, inflammatory pain, neuropathic pain, and traumatic brain injury[1][2][3][4].
Molecular Weight:
304.30
Purity:
99.6
CAS Number:
[723331-20-2]
Formula:
C12H20N2O7
Target:
Aminopeptidase,Carboxypeptidase,mGluR
Application Notes:
MCE Product type: Reference compound
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