Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 µM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 µM and and 0.8 µM for cowpox and monkeypox, respectively[5].
Molecular Weight:
517.40
Purity:
98.98
CAS Number:
[70476-82-3]
Formula:
C22H30Cl2N4O6
Target:
Apoptosis,Orthopoxvirus,PKC,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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