PF-4455242 hydrochloride is an orally bioavailable, blood-brain barrier-permeable kappa-opioid receptor (KOR) inhibitor. PF-4455242 hydrochloride blocks in vivo effects induced by KOR and MOR agonists, and elicits KOR-independent outward currents in ventral tegmental area neurons. PF-4455242 hydrochloride promotes energy expenditure and activates the hypothalamic mTOR pathway. PF-4455242 hydrochloride attenuates stress-induced behavioral effects and produces antidepressant-like effects. PF-4455242 hydrochloride can be used in studies related to pain, depression, addictive disorders, and obesity induced by estrogen withdrawal[1][2][3][4].
Molecular Weight:
408.99
Purity:
99.01
CAS Number:
[1322001-35-3]
Formula:
C21H29ClN2O2S
Target:
mTOR,Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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