Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFalpha-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury[1][2][3].
Molecular Weight:
1605.70
Purity:
99.65
CAS Number:
[1020407-90-2]
Formula:
C75H100N18O22
Target:
Chemerin Receptor,ERK,p38 MAPK,P-selectin,Src,Syk
Application Notes:
MCE Product type: Peptides
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