This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western blot analysis of human liver tissue lysate using Carbamoyl-Phosphate Synthetase (CPS1) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R).
Western blot analysis of Human liver, Mouse Liver and Rat Liver tissue lysates using Carbamoyl-Phosphate Synthetase (CPS1) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R).
SDS-PAGE Analysis of Purified Carbamoyl-Phosphate Synthetase Recombinant Rabbit Monoclonal Antibody (CPS1/13326R). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of Human Brain, Human Heart, Human Intestine, Human Kidney, Human Liver, Human Lung, Human Pancreas, Human Skeletal muscle, Human Skin, Human Spleen and Human Stomach tissue lysates using Carbamoyl-Phosphate Synthetase (CPS1) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R).
Formalin-fixed, paraffin-embedded human hepatocellular carcinoma (HCC) stained with Carbamoyl-Phosphate Synthetase (CPS1) Recombinant Rabbit Monoclonal Antibody (CPS1/13326R). Inset: PBS instead of primary antibody, secondary only negative control.
* VAT and and shipping costs not included. Errors and price changes excepted
