This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
Western Blot Analysis of Human Skin tissue lysate using EGFR-Recombinant Rabbit Monoclonal Antibody (EGFR/9166R).
Western Blot Analysis of Skin tissue lysates of different species using EGFR-Recombinant Rabbit Monoclonal Antibody (EGFR/9166R).
Western Blot Analysis of A431 cell lysate using EGFR-Recombinant Rabbit Monoclonal Antibody (EGFR/9166R).
