Recombinant ERG / ETS Transcription Factor (Prostate Cancer Marker) Antibody, Clone: [ERG/22R], Rabbit, Monoclonal

Article Name:	Recombinant ERG / ETS Transcription Factor (Prostate Cancer Marker) Antibody, Clone: [ERG/22R], Rabbit, Monoclonal
Biozol Catalog Number:	NBT-2078-RBM2-P1
Supplier Catalog Number:	2078-RBM2-P1
Alternative Catalog Number:	NBT-2078-RBM2-P1-100
Manufacturer:	NeoBiotechnologies
Host:	Rabbit
Category:	Antikörper
Application:	IHC, WB
Species Reactivity:	Guinea pig, Hamster, Human, Mouse
Immunogen:	Synthetic peptide corresponding to residues within aa450 to C-terminus of ERG was used as an immunogen
Alternative Names:	ERG, ERG/EWS fusion gene, ERG/FUS fusion gene, ERG/TMPSSR2 fusion gene, ERG1, ETS-related, KCNH2, Oncogene ERG, p55, TMPRSS2/ERG fusion

ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.

Clonality:	Monoclonal
Clone Designation:	[ERG/22R]
Molecular Weight:	55kDa
NCBI:	2078
UniProt:	P11308
Form:	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.Storage and StabilityAntibody with azide - store at 2 to 8 C. Antibody without az

	Formalin-fixed, paraffin-embedded human brain. Neg

	Formalin-fixed, paraffin-embedded human prostate tissue stained with ERG Recombinant Rabbit Monoclonal Antibody (ERG/22R) at 1ug/ml. HIER: Tris/EDTA pH 9, 95°,C/45min. 2°CAb: HRP-Polymer:30mins, DAB:5min.
	Formalin-fixed, paraffin-embedded human brain. Negative tissue control stained with ERG/22R at 1ug/ml for 30 min at RT. HIER: Tris/EDTA pH 9, 95°,C/45min. 2°CAb: HRP-Polymer:30mins, DAB:5min.
	SDS-PAGE Analysis. Purified ERG Recombinant Rabbit Monoclonal Antibody (ERG/22R). Confirmation of Purity and Integrity of Antibody.
	Western Blot analysis of Human Lung tissue lysate using ERG Recombinant Rabbit Monoclonal Antibody (ERG/22R).
	Western Blot Analysis of Human Lung, Mouse Lung, Rat Lung, Hamster Lung, Guinea pig Lung, and Rabbit Lung tissue lysates using ERG Recombinant Rabbit Monoclonal Antibody (ERG/22R).