Recombinant ALK (Anaplastic Lymphoma Kinase) / CD246 Antibody, Clone: [ALK1/6698R], Rabbit, Monoclonal

Article Name:	Recombinant ALK (Anaplastic Lymphoma Kinase) / CD246 Antibody, Clone: [ALK1/6698R], Rabbit, Monoclonal
Biozol Catalog Number:	NBT-238-RBM8-P0
Supplier Catalog Number:	238-RBM8-P0
Alternative Catalog Number:	NBT-238-RBM8-P0-20,NBT-238-RBM8-P0-100
Manufacturer:	NeoBiotechnologies
Host:	Rabbit
Category:	Antikörper
Application:	IHC
Species Reactivity:	Human
Immunogen:	Recombinant human ALK protein fragment around aa 1058-1620 (exact sequence is proprietary)
Alternative Names:	ALK/NPM1 fusion gene, Anaplastic lymphoma kinase Ki1, Anaplastic Lymphoma Kinase p80, anaplastic lymphoma receptor tyrosine kinase, mutant anaplastic lymphoma kinase, NBLST3, Tcrz, TFG/ALK

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system. ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory myo-fibroblastic tumors. ALK may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK. ALK staining is present within both the nucleus and cytoplasm, and are positive in about 60% of ALCL. ALK protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.

Clonality:	Monoclonal
Clone Designation:	[ALK1/6698R]
Molecular Weight:	177kDa
NCBI:	238
UniProt:	Q9UM73
Form:	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:	Recombinant Monoclonal Antibody

Application Notes:

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal diluti

	Formalin-fixed, paraffin-embedded human inflamma

	Formalin-fixed, paraffin-embedded human lung adenocarcinoma stained with ALK-1 Recombinant Rabbit Antibody (ALK1/6698R) at 2ug/ml in PBS. HIER: Tris/EDTA pH9.0, 95°,C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.
	Formalin-fixed, paraffin-embedded human inflammatory myofibroblastic tumor stained with ALK-1 Recombinant Rabbit Antibody (ALK1/6698R) at 2ug/ml. HIER: Tris/EDTA pH9.0, 95°,C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.
	Formalin-fixed, paraffin-embedded human Anaplastic Large Cell Lymphoma stained with ALK-1 Recombinant Rabbit Antibody (ALK1/6698R) at 2ug/ml. HIER: Tris/EDTA pH9.0, 95°,C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.
	SDS-PAGE Analysis of Purified ALK / CD246 Recombinant Rabbit Monoclonal Antibody (ALK1/6698R). Confirmation of Purity and Integrity of Antibody.