Aldoketomutase, epididymis secretory protein Li 74, Glo1, Glx I, glyoxalase 1 complex, glyoxalase 1 regulatory, glyoxalase 1 structural, glyoxalase domain containing 1, Glyoxalase I, glyoxylase 1, Ketone-aldehyde mutase, lactoyl glutathione lyase, Lactoylglutathione lyase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase
GLO1 is an enzyme involved in the detoxification of methylgyoxal, a byproduct of glycolysis. GLO1 expression has been demonstrated by several studies to be upregulated in various human malignant tumors, including metastatic melanoma and lung carcinoma, and thus is a target for pharmaceutical development.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes
SDS-PAGE Analysis of Purified Glyoxalase 1 (GLO1) Mouse Monoclonal Antibody (CPTC-GLO1-1). Confirmation of Integrity and Purity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Glyoxalase 1 (GLO1) Monoclonal Antibody (CPTC-GLO1-1). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
Western Blot Analysis of HeLa cell lysate using Glyoxalase 1 (GLO1) Mouse Monoclonal Antibody (CPTC-GLO1-1).
Formalin-fixed, paraffin-embedded human thyroid carcinoma stained with Glyoxalase 1 (GLO1) Mouse Monoclonal Antibody (CPTC-GLO1-1).
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Glyoxalase 1 (GLO1) Mouse Monoclonal Antibody (CPTC-GLO1-1).
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