PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 2
Formalin-fixed, paraffin-embedded human skin stained with PD-L1 Recombinant Mouse Monoclonal Antibody (rPDL1/4773).
Formalin-fixed, paraffin-embedded human placenta stained with PD-L1 Recombinant Mouse Monoclonal Antibody (rPDL1/4773).
SDS-PAGE Analysis of Purified PD-L1 Recombinant Mouse Monoclonal Antibody (rPDL1/4773). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of NIH3T3, PC3 and MCF-7 cell lysates using PD-L1 Mouse Monoclonal Antibody (PDL1/2746).
Western Blot Analysis of A-549 cell lysates using PD-L1 Recombinant Mouse Monoclonal Antibody (rPDL1/4773).
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