Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human spleen stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
Formalin-fixed, paraffin-embedded human tonsil stained with Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
SDS-PAGE Analysis of Purified GZMB Recombinant Rabbit Monoclonal Antibody (GZMB/6530R). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of Spleen and Lung tissue lysates of different species using Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
Western Blot Analysis of Human Kidney, Human Lung and Human Spleen tissue lysates using Granzyme B Recombinant Rabbit Monoclonal Antibody (GZMB/6530R).
* VAT and and shipping costs not included. Errors and price changes excepted
