The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Western Blot (2-4ug/ml), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for
Wester
Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/6451).
Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/6451).
Western Blot Analysis for A549 cell lysate using Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/6451).
SDS-PAGE Analysis of Purified Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/6451). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human Intestine, Human Lung and A549 lysates using Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/6451).
* VAT and and shipping costs not included. Errors and price changes excepted
