Recombinant fragment of human NPM1 protein (exact sequence is proprietary)
Alternative Names:
NO38, NPM, NPM1, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Nucleophosmin (nucleolar phosphoprotein B23 numatrin), Nucleophosmin, Nucleophosmin/nucleoplasmin family member 1, Numatrin
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm.It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location.Mutations in this gene are associated with acute myeloid leukemia.The antibody may be a useful aid for classification of acute myeloid leukemia.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal diluti
SDS-PAGE Analysis Purified NPM1Recombinant Rabbit Monoclonal Antibody (NPM1/7072R). Confirmation of Integrity and Purity of Antibody.
SDS-PAGE Analysis of Purified NPM1Recombinant Rabbit Monoclonal Antibody (NPM1/7072R). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of Kidney and Stomach tissue lysates of different species using Nucleophosmin Mouse Monoclonal Antibody (NPM1/7072R).
Western Blot Analysis of Human Kidney, Human Skeletal muscle, Human Skin, Human Stomach, K-562, Panc-28, Raji and Ramos lysates using Nucleophosmin Mouse Monoclonal Antibody (NPM1/7072R).
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