Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow Cytometry (0.5-1ug/million cells in 0.1ml), Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT), (Staining of formalin-fixed tissues requires heating tissue sections in 10mM T
Formalin-fixed, paraffin-embedded Rat Pancreas stained with ODC1 Monoclonal Antibody (ODC1/487)
Formalin-fixed, par
IF staining of LNCap cells using AF488 labeled ODC1 Monoclonal Antibody (ODC1/487) (Green). DAPI was used to stain the cell nuclei (blue).
Formalin-fixed, paraffin-embedded Rat Pancreas stained with ODC1 Monoclonal Antibody (ODC1/487)
Formalin-fixed, paraffin-embedded Mouse Pancreas stained with ODC1 Monoclonal Antibody (ODC1/487)
Formalin-fixed, paraffin-embedded Mouse Small Intestine stained with ODC1 MAb (ODC1/487)
SDS-PAGE Analysis Purified ODC1 MAb (ODC1/487). Confirmation of Integrity and Purity of Antibody.
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