CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human Colon stained with CD31 Mouse Monoclonal Antibody (PECAM1/3534).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD31 Mouse Monoclonal Antibody (PECAM1/3534).
Flow Cytometric Analysis of Jurkat cells using CD31 Mouse Monoclonal Antibody (PECAM1/3534), followed by goat anti-mouse IgG-CF488 (Blue), Isotype Control (Red).
Western Blot Analysis of human THP-1 cell lysate using CD31 Mouse Monoclonal Antibody (PECAM1/3534).
Immunofluorescence staining of Jurkat cells using CD31 Mouse Monoclonal Antibody (PECAM1/3534) followed by goat anti-mouse IgG-CF488 (green). Nuclei are stained with RedDot.
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD31 Mouse Monoclonal Antibody (PECAM1/3534) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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