[Myelin basic protein]-arginine N-methyltransferase PRMT7, Histone-arginine N-methyltransferase PRMT7, KIAA1933, Protein arginine methyltransferase 7, Protein arginine N-methyltransferase 7
Arginine methylation is an irreversible protein modification catalyzed by Arginine methyltransferases, such as PRMT7, which uses S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport and RNA splicing. PRMT7 has two methyltransferase domains, each containing a putative AdoMet-binding motif. The N-terminal methyltransferase domain closely resembles the catalytic core of PRMT5, and the C-terminal domain is most similar to that of PRMT1. Three PRMT7 splice variants have been identified by database analysis. PRMT7 is localized to the nucleus and cytoplasm and moderate expression is observed in adult brain and lung tissues.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western blot analysis of HeLa cell lysate using PRMT7 Mouse Monoclonal Antibody (PCRP-
Flow Cytometric Analysis of PFA-fixed HeLa cells. PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Western blot analysis of HeLa cell lysate using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4) followed by goat anti-mouse IgG-CF488 (green).
SDS-PAGE Analysis. Purified PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence Analysis of PFA-fixed U87 cells stained using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4) followed by goat anti-mouse IgG-CF488. Membrane stained with phalloidin.
Analysis of Protein Array containing more than 19,000 full-length human proteins using PRMT7 Mouse Monoclonal Antibody (PCRP-PRMT7-1A4). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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