CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution
Formalin-fixed, paraffin-embedded human Spleen stained with CD162 Monoclonal Antibody (PSGL1/1601).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD162 Monoclonal Antibody (PSGL1/1601).
SDS-PAGE Analysis of Purified CD162 Mouse Monoclonal Antibody (BSG/7953). Confirmation of Purity and Integrity of Antibody.
SDS-PAGE Analysis of Purified CD162 Mouse Monoclonal Antibody (PSGL1/1601). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Spleen stained with CD162 Monoclonal Antibody (PSGL1/1601).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD162 Monoclonal Antibody (PSGL1/1601).
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