SET Antibody, IgG1, Clone: [PCRP-SET-1C6], Mouse, Monoclonal
Biozol Catalog Number:
NBT-6418-MSM1-P1ABX
Supplier Catalog Number:
6418-MSM1-P1ABX
Alternative Catalog Number:
NBT-6418-MSM1-P1ABX-100
Manufacturer:
NeoBiotechnologies
Host:
Mouse
Category:
Antikörper
Application:
FC, IF, WB
Species Reactivity:
Human
Immunogen:
Recombinant full-length human SET protein
Alternative Names:
2PP2A, HLA DR associated protein II, IGAAD, Inhibitor of granzyme A activated DNase, inhibitor-2 of protein phosphatase-2A, IPP2A2, PHAPII, Phosphatase 2A inhibitor I2PP2A, protein phosphatase type 2A inhibitor, TAFI, Template-Activating Factor-I, chromatin remodelling factor, SET nuclear oncogene, SET translocation (myeloid leukemia-associated)
Protein phosphatase 2A (PP2A) is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. Inhibitor 1 of PP2A (I1PP2A) and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. I1PP2A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The I1PP2A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml), ,Optimal dilution for a specific application should be determined.
Flow cytometric analysis of PFA-fixed HeLa cells. SET Mouse Monoclonal Antibody (PCRP-SET
Immunofluorescence Analysis of HeLa cells using SET Mouse Monoclonal Antibody (PCRP-SET-1C6) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Flow cytometric analysis of PFA-fixed HeLa cells. SET Mouse Monoclonal Antibody (PCRP-SET-1C6) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).
SDS-PAGE Analysis of Purified SET Mouse Monoclonal Antibody (PCRP-SET-1C6). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using SET Mouse Monoclonal Antibody (PCRP-SET-1C6). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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