Recombinant human TLE1 fragment (aa 175-338) (exact sequence is proprietary)
Alternative Names:
Enhancer of split groucho 1 (ESG1), Enhancer of split groucho-like protein 1, GRG1, TLE1, Transducin like enhancer of split 1, Transducin-like enhancer protein 1
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein1 (TLE1) is a protein that isencoded by theTLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of human He
Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with TLE1 Mouse Monoclonal Antibody (TLE1/2062).
Formalin-fixed, paraffin-embedded human GIST stained with TLE1 Mouse Monoclonal Antibody (TLE1/2062).
Western Blot Analysis of human HeLa cell lysate using TLE1 Mouse Monoclonal Antibody (TLE1/2062).
SDS-PAGE Analysis Purified TLE1 Mouse Monoclonal Antibody (TLE1/2062). Confirmation of Integrity and Purity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TLE1 Mouse Monoclonal Antibody (TLE1/2062). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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