Recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)
Alternative Names:
5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95
Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Recombinant Rabbit Monoclonal (TYRP1/2340R), DAB Chromogen.
Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Recombinant Rabbit Monoclonal (TYRP1/2340R), AEC Chromogen.
Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R).
SDS-PAGE Analysis of Purified TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of B-16 cell lysate using Tyrosinase Related Protein Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R).
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