This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinsons disease.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minu
Formalin-fixed, paraffin-embedded Rat Testis stained with Pgp9.5 Monoclonal Antibody (UCHL1/775).
Western Blot Analysis of human brain tissue lysate usi
Formalin-fixed, paraffin-embedded Rat Testis stained with Pgp9.5 Monoclonal Antibody (UCHL1/775).
Formalin-fixed, paraffin-embedded Rat Cerebellum stained with Pgp9.5 Monoclonal Antibody (UCHL1/775).
Western Blot Analysis of human brain tissue lysate using Pgp9.5 Monoclonal Antibody (UCHL1/775).
SDS-PAGE Analysis of Purified Pgp9.5 MAb (UCHL1/775). Confirmation of Purity and Integrity of Antibody.
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