BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1,14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF B activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1,14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human tonsil stained with BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R).
SDS-PAGE Analysis of Purified BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of PFA-fixed K562 cells. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-Rabbit IgG-CF488 (blue), isotype control (red).
Immunofluorescence Analysis of PFA-fixed K562 cells labeling BCL10. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-rabbit IgG-CF488 (green). Phalloidin counterstain (red).
Western Blot Analysis of K-562 and Raji lysates using BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R).
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