Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 2
Formalin-fixed, paraffin-embedded human lymph
Formalin-fixed, paraffin-embedded human lymph node stained with CD7 Mouse Monoclonal Antibody (CD7/3737).
Formalin-fixed, paraffin-embedded human tonsil stained with CD7 Mouse Monoclonal Antibody (CD7/3737).
Formalin-fixed, paraffin-embedded human lymph node stained with CD7 Mouse Monoclonal Antibody (CD7/3737).
Western blot analysis of HePG-2 cell lysate using CD7 Mouse Monoclonal Antibody (CD7/3737).
SDS-PAGE Analysis of Purified CD7 Mouse Monoclonal Antibody (CD7/3737). Confirmation of Purity and Integrity of Antibody.
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