PDX1 Antibody / Pyruvate dehydrogenase protein X / PDXH, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F47892-0.08ML
Supplier Catalog Number:
F47892-0.08ML
Alternative Catalog Number:
NSJ-F47892-0.08ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IF, IHC, WB
Species Reactivity:
Human
Immunogen:
A portion of amino acids 1-30 from the human protein was used as the immunogen for this PDX1 antibody.
PDX1/PDHX, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.
